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. 2021 Sep 14;12:706737. doi: 10.3389/fimmu.2021.706737

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Copyright © 2021 Pontarini, Sciacca, Grigoriadou, Rivellese, Lucchesi, Fossati-Jimack, Coleby, Chowdhury, Calcaterra, Tappuni, Lewis, Fabris, Quartuccio, Bella, Bowman, Pitzalis, Mavilio, De Vita and Bombardieri

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKp30 and B7/H6 expression post-Rituximab treatment. (A) Baseline expression of NCR3 (NKp30), NCR3LG1 (B7/H6), GZMB, and IFNG between placebo and rituximab salivary glands. Mann–Whitney U t-test statistics. (B) Volcano plot of DEGs using DESeq2 comparing rituximab versus placebo patients after 48 weeks of treatment. Comparison between groups using Wald test and correcting for multiple testing Storey’s q-value (q < 0.05 = significant, shown in green). Positive values represent upregulation in rituximab and negative values denote downregulation in rituximab-treated patients compared to placebo. (C) Longitudinal analysis fitting a mixed effects linear model of NCR3, NCR3LG1, IFNG, and GZMB genes for rituximab (21 samples, 10 individuals) and placebo (29 samples, 15 individuals). The scatter plot shows the assessed normalized expression level of each sample over time overlaid by the fitted model (in blue) with 95% confidence intervals (fixed effects).