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. 2021 Sep 14;12:715997. doi: 10.3389/fimmu.2021.715997

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Copyright © 2021 O’Neil, Oliveira, Sandoval-Heglund, Barrera-Vargas, Merayo-Chalico, Aguirre-Aguilar, Kaplan and Carmona-Rivera

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CarLL37-IgG immune complexes enhance osteoclast formation and function. (A) Representative pictures of M-CSF/RANKL-mediated osteoclastogenesis in the presence or absence of anti-carbamylated LL37 IgG immune complexes. Original magnification is 400X. (B) Quantification of TRAP-positive multinucleated cells. Results are the mean +/- SEM of 4-5 independent experiments. Kruskal-Wallis test was used. ****p < 0.0001. (C) Representative pictures of resorption pit (white areas) assay of equal number of M-CSF/RANKL generated osteoclasts (OC) in the presence or absence of anti-carbamylated LL37-IgG immune complexes in a calcium-phosphate plate. (D) Percentage of eroded surface using ImageJ. Results are the mean +/- SEM of 10 independent experiments. Mann-Whitney U-test was used. *p < 0.05, **p < 0.01, ****p < 0.0001.