Table 2.

Taxa showing a significant different in the abundance between CRC with control in the gut microbe-derived extracellular vesicles.

Taxon	t-statistic	Unadjusted p-value	Adjusted p-value
Phylum Firmicutes	3.16	0.002	0.008
Family Clostridiaceae 1	-3.36	0.001	0.019
Genus Clostridium sensu stricto 1	-3.36	0.001	0.003
Family Erysipelotrichaceae	3.28	0.001	0.019
Genus Catenibacterium	7.51	<0.001	0.004
Genus Erysipelotrichaceae UCG-003	4.41	<0.001	0.004
Genus Turicibacter	-2.00	0.043	0.541
Family Ruminococcaceae	4.22	<0.001	0.002
Genus Faecalibacterium	3.41	<0.001	0.020
Genus Ruminococcus 1	2.96	0.004	0.089
Genus Ruminococcus 2	2.23	0.028	0.028
Family Lachnospiraceae
Genus Blautia	3.78	<0.001	0.012
Genus [Eubacterium] hallii group	5.04	<0.001	0.004
Genus [Ruminococcus] torques group	4.85	<0.001	0.004
Genus Oribacterium	3.79	<0.001	0.012
Genus Dorea	3.91	0.004	0.018
Genus Lachnospiraceae UCG-008	2.52	0.012	0.230
Family Peptostreptococcaceae	-3.25	0.003	0.033
Genus Romboutsia	-4.35	<0.001	0.001
Genus Terrisporobacter	-3.56	<0.001	0.003
Genus Intestinibacter	-3.07	0.004	0.092
Family Veillonellaceae	-6.10	<0.001	0.002
Genus Dialister	-6.10	<0.001	0.004
Family Staphylococcaceae	-4.61	<0.001	0.002
Genus Staphylococcus	-4.61	<0.001	0.004
Family Acidaminococcaceae	-3.28	0.001	0.018
Phylum Proteobacteria
Family Moraxellaceae
Genus Enhydrobacter	-2.15	0.034	0.476
Phylum Actinobacteria
Family Coriobacteriaceae	4.78	<0.001	0.004
Genus Collinsella	4.78	<0.001	0.007
Phylum Verrucomicrobia	-3.77	<0.001	0.002
Family Akkermansiaceae	-3.77	<0.001	0.004
Genus Akkermansia	-3.77	<0.001	0.012

The change of column (log2 fold) represents the multiplicative change in taxa abundance from CRC to control.

Negative numbers represent a trend of decreasing abundance in CRC group compared with control group.

The data (p < 0.05) was provied as bold values.