Figure 4.

Plasma levels of the four miRNAs in patients with NSCLC with different stages of cancer and healthy controls, and associated ROC curve analyses. (A) The plasma levels of the four miRNAs were significantly upregulated in patients with stage I–IIIA NSCLC compared with the healthy controls. (B) ROC curve analyses were performed on the four individual miRNAs to distinguish patients with NSCLC with different stages (stage I, stage II and stage IIIA) from healthy individuals. ROC curve analysis of the four-miRNA panel in the training and testing sets were combined to distinguish (C) patients with stage I NSCLC or (D) patients with stage II–IIIA NSCLC from healthy individuals, and associated diagnostic performance. miRNA/miR, microRNA; NSCLC, non-small cell lung cancer; ROC, receiver operating characteristic; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value.