Table I.

Expression of the COPS families in head and neck squamous cell carcinoma.

Gene name	Cancer type (n)	P-value	Fold change	T-test	(Refs.)
COPS1	Floor of the mouth carcinoma (5)	4.00×10−3	1.543	3.837	Pyeon Multi-cancer (50)
COPS2	Nasopharyngeal carcinoma (31)	2.80×10−6	2.095	5.746	Sengupta Head-Neck (36)
	Floor of the mouth carcinoma (5)	2.07×10−4	2.261	5.383	Pyeon Multi-cancer (50)
COPS3	Oropharyngeal carcinoma (6)	3.32 ×10−4	2.295	4.225	Pyeon Multi-cancer (50)
	Oral cavity carcinoma (4)	3.00×10−3	2.206	3.717	Pyeon Multi-cancer (50)
	Floor of the mouth carcinoma (5)	2.43×10−4	2.636	4.748	Pyeon Multi-cancer (50)
	Tongue carcinoma (15)	2.01×10−4	2.040	3.913	Pyeon Multi-cancer (50)
COPS5	Tongue carcinoma (15)	3.88×10−4	2.755	6.009	Pyeon Multi-cancer (50)
	Floor of the mouth carcinoma (5)	1.71×10−6	4.533	8.121	Pyeon Multi-cancer (50)
	Oral cavity carcinoma (4)	2.26 ×10−4	2.401	4.971	Pyeon Multi-cancer (50)
	Tonsillar carcinoma (6)	9.52×10−4	1.719	3.509	Pyeon Multi-cancer (50)
	Oropharyngeal carcinoma (6)	1.99×10−4	2.762	4.910	Pyeon Multi-cancer (50)
	Oral cavity squamous cell carcinoma (16)	3.88×10−4	1.823	4.826	Toruner Head-Neck Statistics (53)
	Nasopharyngeal carcinoma (31)	1.17×10−4	1.595	4.233	Sengupta Head-Neck Statistics (36)
COPS6	Tonsillar carcinoma (6)	3.01×10−4	1.924	3.915	Pyeon Multi-cancer (50)
	Oral cavity carcinoma (4)	2.00×10−3	2.634	3.902	Pyeon Multi-cancer (50)
	Oropharyngeal carcinoma (6)	4.81×10−4	2.118	3.820	Pyeon Multi-cancer (50)
	Floor of the mouth carcinoma (5)	1.49×10−4	2.665	4.656	Pyeon Multi-cancer (50)
COPS8	Hypopharyngeal squamous cell carcinoma (4)	5.00×10−3	2.533	3.794	Schlingemann Head-Neck (52)
	Head and neck squamous cell carcinoma (34)	6.70×10−4	2.001	5.820	Cromer Head-Neck (52)
	Head and neck squamous cell carcinoma (41)	3.48×10−9	1.617	7.125	Ginos Head-Neck (54)
	Oropharyngeal carcinoma (6)	1.21×10−4	2.021	4.791	Pyeon Multi-cancer (50)
	Nasopharyngeal carcinoma (31)	2.47×10−4	1.523	3.957	Sengupta Head-Neck (36)

COPS, COP9 signalosome.