Table 3.

Anxiety and depression screening sensitivity, specificity & 95% CI estimates by instrument (n=422)

Instrument, positive values (reference)	AUC	Sensitivity	Sensitivity 95% CI*	Specificity	Specificity 95% CI*
GAD-2, > 2 (GAD-7, ≥ 10)	0.98	0.95	0.89–0.98	0.90	0.86–0.93
GAD-SI, ≥ 2 (GAD-7, ≥ 10)	0.89	0.72	0.62–0.80	0.93	0.90–0.95
NDDIE-2, > 4 (NDDI-E, ≥ 16)	0.96	0.78	0.68–0.85	0.95	0.92–0.97
NDDIE-2, >3 (NDDI-E, ≥ 16)	0.96	1.0	0.96–1.0	0.80	0.76–0.84
PHQ-2, >0 (NDDI-E, ≥ 16)	0.50	0.0	0.0–0.043	1.0	0.98–1.0

Confidence interval, CI; Generalized Anxiety Disorder −7, GAD-7; Generalized Anxiety Disorder-2, GAD-2; Single-item GAD, GAD-SI; Neurological Disorders Depression Inventory-Epilepsy, NDDI-E; Neurological Disorders Depression Inventory Epilepsy-2, NDDIE-2

^*Confidence intervals are calculated on the basis of inverting the score test for a binomial proportion.