Table 1.

Potential CADA-affected SILAC targets selected for validation

UniProt_ID	Protein	Function	Cellular localization	Ratio H/La	Ratio L/Hb
P01730	Human T-cell surface glycoprotein CD4 (cluster of differentiation 4)	Major histocompatibility complex class-II antigen/T-cell coreceptor	Cell surface	3.63	3.61
Q13308	Human PTK7, CCK-4 (colon carcinoma kinase 4)	Inactive tyrosine kinase involved in Wnt signaling pathway, both the noncanonical (Wnt/planar cell polarity signaling) and the canonical pathway	Cell surface	2.39	2.49
Q13217	Human DNAJC3, ERdj6 (endoplasmic reticulum DNA J domain–containing protein 6)	Involved in the unfolded protein response (UPR) during ER stress	ER lumen	2.16	2.93
Q99523	Sortilin, NTR3 (human neurotensin receptor 3)	Sorting receptor in the Golgi compartment, required for protein transport from the Golgi apparatus. Also acts as a receptor for neurotensin	Nucleus, ER, Golgi, and cell surface	2.07	3.48
Q96DZ1	Human ERLEC1, XTP3B (XTP3-transactivated gene B protein)	Probable lectin that binds selectively to improperly folded lumenal proteins. May function in ER quality control and ERAD	ER lumen	2.00	2.11

^aRatio of the heavy sample (H) over light sample (L).

^bRatio of the light sample (L) over heavy sample (H).