Table 1.
Nine of the 1000 SNPs with the lowest P-values in a GWAS for AN risk (GCAN9) are associated with decreased BMI (GIANT11, with Bonferroni-corrected P < 0.05 significance; sorted according to the nominal P-values for BMI in all GIANT participants)
| Chromosome/position/SNP nearest gene(s) | Location | Rank in AN GWAS | AN reference allele/frequency in AN cases | Odds ratio (s.e.m.) for AN reference allele | P-value for AN risk | BMI reference allele/frequency in GIANT | β (s.e.m.) for BMI reference allele | Nominal P-value for BMI: all female/male | Bonferroni corrected P-valuea | Direction of effect (+/−)b |
|---|---|---|---|---|---|---|---|---|---|---|
| 10/126685663 rs1561589 CTBP2 |
Intron | 201 | G/0.67 | 1.14 (0.04) | 7.74 × 10−5 | G/0.66 | −0.0157 (0.0033) | 2.47 ×
10−6 3.45 × 10−7/0.043 |
0.0025 | + |
| 10/126681170 rs12771627 CTBP2 |
Intron | 190 | A/0.25 | 0.87 (0.03) | 7.28 × 10−5 | A/0.26 | 0.0162 (0.0035) | 4.25 ×
10−6 5.8 × 10−6/0.022 |
0.0043 | + |
| 10/126674064 rs11245456 CTBP2 |
Intron | 177 | G/0.25 | 0.87 (0.03) | 6.79 × 10−5 | G/0.25 | 0.0171 (0.0037) | 4.58 ×
10−6 1.03 × 10−5/0.009 |
0.0046 | + |
| 19/34978662 rs17513613 CCNE1 |
Distant 5′ | 409 | C/0.30 | 0.88 (0.03) | 0.0002 | C/0.33 | 0.015 (0.0033) | 5.41 ×
10−6 6.4 × 10−3/1.24 × 10−5 |
0.0054 | + |
| 2/203492447 rs17406900 CARF |
Intron | 709 | G/0.52 | 0.90 (0.03) | 0.0003 | G/0.51 | 0.0134 (0.0031) | 1.08 ×
10−5 1.8 × 10−4/2.27 × 10−3 |
0.0108 | + |
| 2/203639257 rs7593917 NBEAL1 |
Intron | 444 | G/0.54 | 0.89 (0.03) | 0.0002 | G/0.54 | 0.0131 (0.0031) | 2.48 ×
10−5 9.54 × 10−5/9.39 × 10−3 |
0.0248 | + |
| 2/203582157 rs11691351 NBEAL1 |
Distant 5′ | 412 | G/0.54 | 0.89 (0.03) | 0.0002 | G/0.54 | 0.0126 (0.0031) | 3.57 ×
10−5 1.98 × 10−4/8.21 × 10−3 |
0.0357 | + |
| 19/34988693 rs8102137 CCNE1 |
Distant 5′ | 248 | C/0.30 | 0.88 (0.03) | 9.45 × 10− 5 | C/0.33 | 0.0169 (0.0041) | 3.76 ×
10−5 0.006/2.46 × 10−4 |
0.0376 | + |
| 2/203635796 rs7573079 NBEAL1 |
Intron | 401 | A/0.54 | 0.89 (0.03) | 0.0002 | A/0.54 | 0.0124 (0.0031) | 4.61 ×
10−5 2.80 × 10−4/0.008 |
0.0461 | + |
Abbreviations: AN, anorexia nervosa; BMI, body mass index; CARF, calcium-responsive transcription factor; CCNE1, cyclin E1; CTBP2, C-terminal binding protein 2; GCAN, Genetic Consortium for AN; GIANT, Genetic Investigation of ANthropometric Traits; GWAS, genome-wide association studies; NBEAL1, neurobeach inlike 1, SNP, single-nucleotide polymorphism.
a
Primary analysis, sex-combined, correction for 1000 test.
b
Direction of effect: ‘+’ the effect/risk allele for decreased BMI and AN risk are identical.