FIGURE 8.

Telmisartan improves glucose tolerance in db/db mice, elevates GSIS levels in isolated islets, and exerts similar electrophysiological effects on β-cells of db/db mice. (A) OGTT was performed and AUCs for OGTT were calculated from the data in 8-wk-old mice. (B) OGTT and AUC for OGTT in 11-wk-old mice. (C) Serum insulin levels at corresponding times and AUC in 11-wk-old mice. (D) Db/db mice islets were treated with or without telmisartan (10 μM) under different glucose concentrations (2.8, 16.7, and 30 mM) (n = 6 tubes of islet). (E) Representative Kv channels current trances recorded with treatment of telmisartan (10 μM) in β-cells. (F) Current-voltage relationship curves and the summary of the mean current density of Kv channels recorded at 80 mV depolarization (n = 6 cells). (G) Representative Ca²⁺ current trances recorded with treatment of telmisartan (10 μM) in β-cells. (H) Current-voltage relationship curves and the summary of the mean Ca²⁺(Continued)