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. 2021 Sep 27;9(9):e002647. doi: 10.1136/jitc-2021-002647

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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TCR clonality is associated with immune processes and premalignant lesion outcome. (A) Clonotypes per kilo-read (CPK) is negatively correlated with a gene expression module of interferon response previously shown to be negatively associated with lesion progression (p=4.0e-4). (B) CPK in proliferative molecular subtype lesions by progression status (progressive/persistent lesions: purple; regressive lesions: turquoise). Progressive lesions have significantly higher CPK than regressing lesions (p=0.045, n=22 progressive/persistent and n=28 regressive samples, n=23 patients).