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. 2021 Aug 9;64(16):12245–12260. doi: 10.1021/acs.jmedchem.1c00887

Figure 3.

Figure 3

Cytotoxicity of PEI-BP-CD (20–22a,b) and PEI-MP-CD (22a,b) ternary conjugates in different cell lines. HeLa cells (A), MC3T3 osteoblasts (B), and MG-63 sarcomas (C) were incubated with 1–30 μM ALN or PEI-BP derivatives for 48 h, and the cell cytotoxicity (expressed as the percentage of the cell viability of the untreated cells minus the cell viability of treated cells) was determined by an MTT assay. Data are shown as mean ± SEM (n = 5). (D) MG-63 cells were incubated in the absence or presence of 15 μM PEI-BP or ALN for 30 min. The phosphorylative status of Akt and ERK1/2 was measured by Western blot. Data are shown as mean ± SEM (n = 4). *p < 0.05 vs nontreated (C) cells and #p < 0.05 vs ALN-treated cells.