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. 2021 Aug 9;64(16):12245–12260. doi: 10.1021/acs.jmedchem.1c00887

Figure 5.

Figure 5

Effects of inhibitors of internalization routes on DOX ⊂ 21b uptake. HeLa (H) and MG-63 sarcoma (M) cells were pretreated with chlorpromazine (50 μM), sucrose (0.45 M), filipin (5 μg/mL), genistein (400 μM), cytochalasin D (2 μM), or BSP (0.25 mM) for 30 min before incubation with DOX ⊂ 21b (1 μM). DOX uptake was determined 2 h later. Results are expressed as relative uptake values normalized for a 100% value in the absence of inhibitors for each cell line as mean ± SEM (n = 6). *p < 0.05 vsDOX ⊂ 21b-treated cells.