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. Author manuscript; available in PMC: 2021 Sep 28.
Published in final edited form as: Cell Rep. 2021 May 11;35(6):109113. doi: 10.1016/j.celrep.2021.109113

Figure 2. Treatment with the vancomycin, neomycin, and ampicillin (VNA) antibiotics cocktail reduces perivascular inflammation and ISGs in the lungs of SAVI mice.

Figure 2.

Four-week-old STING N153S (SAVI) mice were administered VNA cocktail or vehicle control ad libitum and euthanized at age 12 weeks.

(A) Representative hematoxylin and eosin-stained images of lung sections from age-matched 12-week-old STING N153S mice and littermate control mice. Top panel images were taken under low magnification, and bottom panel images were taken under high magnification. Scale bars: 100 μm.

(B) Quantitation of affected lung area of STING N153S mice following administration of VNA or control.

(C–E) 16S analysis on stool samples collected from 12-week-old, co-housed WT and STING N153S littermates.

(F–K) Gene expression of ISGs, cytokines, and chemokines following administration of VNA or control. Data represent the mean ± SEM of n = 5–13 mice per genotype pooled from 3 independent experiments. Results were analyzed by Mann-Whitney test. *p < 0.05; ***p < 0.001.