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a, Model of a hair cell. b, MET channel complex components: TMC1 or TMC2, TMIE and LHFPL5 are localized to the stereocilia tips. Tip links are formed by dimers of PCDH15 and cadherin 23 (CDH23). c, Cartoon model of components of the MET channel complex: PCDH15 forms the lower half of the tip link (green) and LHFPL5 is a dimeric TM protein (blue) (PDB: 6C13 and 6C14).
