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. 2021 Sep 10;12:744799. doi: 10.3389/fimmu.2021.744799

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Copyright © 2021 Leite, Ferreira, Tashima, Nishiduka, Cunha-Neto, Brunialti, Assuncao, Azevedo, Freitas, van der Poll, Scicluna and Salomão

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression levels of relevant mRNA from over-represented pathways were analyzed by qPCR comparing septic patients (n = 7) with healthy volunteers (n = 7). Results are expressed as the relative gene expression (2^-∆∆Ct). (A) Genes related with transcriptional processes (POLR2H, NCBP2 and GTF2F1). (B) Genes related with translational processes (RPL11, RPS21 and EIF2AK2). (C) Genes related with mitochondrial translation (MRRF, GFM1 and MRPS34). (D) Genes related with extravasation of leukocytes, killing of bacteria and neutrophils (ADAM8, CLEC4D, GCA and ELANE). Data are presented in box plots showing all individual values. P-values were determined using student’s t test.