Table 3.
Mixed linear analysis for time-integrated mean arterial pressure (MAP) area (mmHg min) between the lower and upper MAP bounds for maintained cerebrovascular reactivity (CVR) and total MAP area below the lower and above the upper MAP bound for maintained CVR stratified by the factorial design groups during three time periods: 0–12 h, 12–24 h and 24–48 h, with good or poor neurologic outcomes
| 0–12 h | 12–24 h | 24–48 h | p-value | |
|---|---|---|---|---|
| MAP area between lower and upper MAP bounds, mmHg min | ||||
| All patients | 5399 (3950–8231) | 7958 (4818–11079) | 15870 (9423–21785) | |
| Good outcome | 6900 (4849–8880) | 8389 (5166–11479) | 17277 (10180–22792) | 0.246 |
| Poor outcome | 5542 (3292–6903) | 6134 (3500–9262) | 12139 (6305–16794) | |
| MAP area below lower MAP bound, mmHg min | ||||
| All patients | 132 (36–479) | 107 (31–305) | 235 (6–653) | |
| Good outcome | 118 (33–358) | 103 (28–319) | 235 (54–503) | 0.061 |
| Poor outcome | 150 (46–502) | 134.6 (54.2–358.3) | 197 (85–1153) | |
| MAP area above upper MAP bound, mmHg min | ||||
| All patients | 315 (100–846) | 195 (55–1004) | 266 (99–101) | |
| Good outcome | 319 (96–800) | 135 (28–338) | 222 (79–1011) | 0.243 |
| Poor outcome | 314 (108–1369) | 253 (64–10492) | 339 (149–1010) |
Values are expressed as medians (interquartile ranges)