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. 2021 Sep 27;40:302. doi: 10.1186/s13046-021-02087-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Direct co-culture of chemotherapy-exposed MSC and breast cancer cells. (A) Flow cytometry analysis of gap junctions showed higher percentage of double-positive MDA and JIMT cells (red) in co-culture with DOX-/PAC-MSC compared to unexposed MSC. (B) Cytokine secretion analysis in tumor cell-MSC co-culture. (C) The effect of chemotherapy-exposed MSC on tumor cells proliferation analyzed by IncuCyte ZOOM™ kinetic imaging system. For statistical evaluation, the one-way ANOVA with Turkey´s or the Dunnett T3 multiple comparison test was used, where the cytokine production in unexposed MSC or tumor cells mixed with unexposed MSC was set as a control. * p < 0.05, ** p < 0.01, *** p < 0.001