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. 2021 Sep 27;40:303. doi: 10.1186/s13046-021-02105-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A In vitro cytotoxicity of Au NR@PAMAM-GX1 on HCT-8 cells and L929 cells over an evaluation period of 24 h. B Cell viability of HCT-8 cells pretreated by Au NR@PAMAM-GX1 with different concentrations with and without NIR irradiation. C CCK-8 assay of HCT-8 cells viability after treatment with the Au NR@PAMAM-GX1or Au NR@PAMAM -GX1/FAM172A polyplexes (N/P = 40: 1, 1 μg FAM172A per well) for 24 h, followed by laser irradiation for 5 min (1: PBS; 2: Au NR@PAMAM-GX1; 3: Au NR@PAMAM-GX1/FAM172A). D Images of PI and Calcein-AM double-stained HCT-8 cells under different treatments. E Flow cytometry analysis of HCT-8 cell apoptosis in different treatment groups