TABLE 3.

Multivariable Regression Analyses of Pediatric Septic Shock Outcomes, Adjusted for Age, Gender, Ancestry, and Illness Severity

Outcome	Variable	n	OR (95% CI)	p
Complicated course	Allele status	503	1.76 (1.14–2.70)	0.01
	Age		0.92 (0.86–0.98)	0.01
	Gender		1.30 (0.84–2.01)	0.23
	Ancestry		0.80 (0.49–1.30)	0.37
	PRISM III		1.09 (1.06–1.11)	< 0.01
28-d mortality	Allele status	503	2.07 (1.09–3.96)	0.03
	Age		0.92 (0.82–1.02)	0.10
	Gender		1.24 (0.64–2.41)	0.53
	Ancestry		1.10 (0.52–2.34)	0.79
	PRISM III		1.09 (1.06–1.13)	< 0.01
Patients homozygous for rs688 excluded
Complicated course	Allele status	430	2.10 (1.31–3.37)	< 0.01
	Age		0.92 (0.86–0.99)	0.03
	Gender		1.43 (0.89–2.30)	0.13
	Ancestry		0.71 (0.42–1.18)	0.18
	PRISM III		1.09 (1.06–1.14)	< 0.01
28-d mortality	Allele status	430	2.97 (1.42–6.22)	< 0.01
	Age		0.94 (0.84–1.05)	0.25
	Gender		1.35 (0.64–2.83)	0.42
	Ancestry		0.94 (0.42–2.08)	0.87
	PRISM III		1.10 (1.06–1.14)	< 0.01

OR = odds ratio, PRISM III = Pediatric Risk of Mortality III.