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. 2021 Sep 22;24(5):818. doi: 10.3892/mmr.2021.12458

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — miR-205-5p knockdown inhibits NLRP3 inflammasome activation. (A) Western blot analysis of NLRP3 inflammasome components in the nasal mucosa. (B) Expression analysis of NLRP3 and ASC. (C) Relative expression levels of pro-IL-1β and mature IL-1β, and the mature IL-1β/pro-IL-1β ratio. (D) Relative expression levels of pro-caspase-1 and cleaved caspase-1, and the cleaved caspase-1/pro-caspase-1 ratio. Data are presented as the mean ± SD (n=7). **P<0.01 vs. Sham; ^##P<0.01 vs. AR + NC. AR, allergic rhinitis; ASC, apoptosisassociated specklike protein containing a CARD; miR, microRNA; NC, negative control; NLRP3, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3.