Table 2.
Overall and stratified hazard ratios of all-cause mortality comparing ACTUR with SEER among glioma cases diagnosed between 1987 and 2013
| Variables | Numbers | Adjusted HR (95% CI)* | p-value# | |
|---|---|---|---|---|
| All cases | Deaths | |||
| Overall | ||||
| SEER | 4462 | 2775 | 1.00 (ref.) | |
| ACTUR | 2231 | 1365 | 0.74 (0.67–0.83) | <0.001 |
| By age groups | ||||
| 18–39 | ||||
| SEER | 1880 | 649 | 1.00 (ref.) | |
| ACTUR | 940 | 299 | 0.77 (0.63–0.95) | 0.022 |
| 40–54 | ||||
| SEER | 984 | 671 | 1.00 (ref.) | |
| ACTUR | 492 | 338 | 0.69 (0.56–0.85) | 0.001 |
| 55–69 | ||||
| SEER | 1116 | 993 | 1.00 (ref.) | |
| ACTUR | 558 | 499 | 0.73 (0.60–0.88) | 0.002 |
| 70 or older | ||||
| SEER | 482 | 462 | 1.00 (ref.) | |
| ACTUR | 241 | 229 | 0.80 (0.60–1.05) | 0.168 |
| By sex | ||||
| Male | 3108 | 1953 | 1.00 (ref.) | |
| SEER | 1554 | 956 | 0.73 (0.64–0.83) | <0.001 |
| ACTUR | ||||
| Female | ||||
| SEER | 1354 | 822 | 1.00 (ref.) | |
| ACTUR | 677 | 409 | 0.75 (0.62–0.91) | 0.007 |
| By race | ||||
| White | ||||
| SEER | 4050 | 2515 | 1.00 (ref.) | |
| ACTUR | 2025 | 1245 | 0.82 (0.75–0.90) | <0.001 |
| Black | ||||
| SEER | 280 | 175 | 1.00 (ref.) | |
| ACTUR | 140 | 78 | 0.49 (0.33–0.73) | 0.001 |
| Asian or Pacific Islander | ||||
| SEER | 108 | 75 | 1.00 (ref.) | |
| ACTUR | 54 | 36 | 0.51 (0.22–1.16) | 0.168 |
| By year of diagnosis | ||||
| 1987–1989 | ||||
| SEER | 480 | 324 | 1.00 (ref.) | |
| ACTUR | 240 | 150 | 0.60 (0.30–1.19) | 0.195 |
| 1990–1994 | ||||
| SEER | 1060 | 719 | 1.00 (ref.) | |
| ACTUR | 530 | 361 | 0.63 (0.44–0.91) | 0.022 |
| 1995–1999 | ||||
| SEER | 804 | 525 | 1.00 (ref.) | |
| ACTUR | 402 | 270 | 0.93 (0.75–1.17) | 0.655 |
| 2000–2004 | ||||
| SEER | 756 | 504 | 1.00 (ref.) | |
| ACTUR | 378 | 230 | 0.71 (0.58–0.87) | 0.003 |
| 2005–2009 | ||||
| SEER | 754 | 457 | 1.00 (ref.) | |
| ACTUR | 377 | 207 | 0.63 (0.50–0.80) | <0.001 |
| 2010–2013 | ||||
| SEER | 608 | 246 | 1.00 (ref.) | |
| ACTUR | 304 | 147 | 0.85 (0.63–1.15) | 0.361 |
| By histology | ||||
| Glioblastoma | ||||
| SEER | 1930 | 1734 | 1.00 (ref.) | |
| ACTUR | 965 | 888 | 0.77 (0.67–0.89) | 0.001 |
| Non-glioblastoma astrocytomas | ||||
| SEER | 1564 | 758 | 1.00 (ref.) | |
| ACTUR | 782 | 344 | 0.69 (0.56–0.85) | 0.001 |
| Oligodendroglial tumors | ||||
| SEER | 634 | 166 | 1.00 (ref.) | |
| ACTUR | 317 | 72 | 0.79 (0.53–1.18) | 0.320 |
| Ependymoma | ||||
| SEER | 94 | 19 | 1.00 (ref.) | |
| ACTUR | 47 | 11 | 0.95 (0.19–4.76) | 0.951 |
| Other gliomas | ||||
| SEER | 240 | 98 | 1.00 (ref.) | |
| ACTUR | 120 | 50 | 1.04 (0.60–1.79) | 0.929 |
| By Surgery | ||||
| Yes | 3445 | 2006 | 1.00 (ref.) | |
| SEER | 1625 | 921 | 0.75 (0.66–0.86) | <0.001 |
| ACTUR | ||||
| No | ||||
| SEER | 974 | 736 | 1.00 (ref.) | |
| ACTUR | 523 | 377 | 0.57 (0.39–0.83) | 0.007 |
| Unknown | ||||
| SEER | 43 | 33 | 1.00 (ref.) | |
| ACTUR | 83 | 67 | 1.31 (0.39–4.42) | 0.712 |
| By Radiation | ||||
| Yes | ||||
| SEER | 3012 | 2081 | 1.00 (ref.) | |
| ACTUR | 1464 | 980 | 0.92 (0.65–1.30) | 0.712 |
| No | ||||
| SEER | 1336 | 617 | 1.00 (ref.) | |
| ACTUR | 659 | 311 | 0.74 (0.65–0.85) | <0.001 |
| Unknown | ||||
| SEER | 114 | 77 | 1.00 (ref.) | |
| ACTUR | 108 | 74 | 0.73 (0.48–1.11) | 0.195 |
*
All HRs were estimated from multivariable Cox proportional hazard model for matched data. In the overall analysis, HR was further adjusted for age (as continuous variable), Hispanic origin, tumor grade, tumor location, surgery and radiation. In stratified analysis, all variables adjusted in the overall analysis were adjusted except the stratified variable itself.
#
All p values were corrected for multiple comparisons.
HR=Hazard ratio; CI=Confidence Interval