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. Author manuscript; available in PMC: 2021 Sep 28.
Published in final edited form as: Trends Biochem Sci. 2020 May 6;45(9):731–747. doi: 10.1016/j.tibs.2020.04.002

Figure 2: Reversible histone acetylation/acylation reaction diagrams and acetyl-CoA metabolism schematic.

Figure 2:

(A-B) Enzyme reaction diagrams illustrating the reversibility of histone lysine acetylation/acylation for Class I, II, and IV histone deacetylases (HDACs) (A) as well as Class III HDACs (B). (C) Schematic detailing acetyl-CoA metabolism and enzymes implicated in regulating global and/or loci specific histone acetyltransferase (HAT) reactions. Enzyme abbreviations: ACLY (ATP-citrate synthase); ACSS1–3 (acyl-CoA synthetase short-chain family member 1–3); PDC (pyruvate dehydrogenase complex).