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. Author manuscript; available in PMC: 2021 Sep 28.
Published in final edited form as: Trends Biochem Sci. 2020 May 6;45(9):731–747. doi: 10.1016/j.tibs.2020.04.002

Figure 4: Reversible chromatin methylation reaction diagrams and SAM metabolism schematic.

Figure 4:

(A-B) Enzyme reaction diagrams illustrating reversibility of histone (A) and DNA (B) methylation. (C) Schematic highlighting position of SAM-synthesizing reactions at the crossroads of the folate and methionine cycles. Enzyme abbreviations: HMT (histone methyltransferase); HDM (histone demethylase); DNMT (DNA methyltransferase); TET (DNA demethylase); TDG (thymine DNA glycosylase); base excision repair (BER); MATI/IIα (methionine adenosyltransferase I/IIα).