Figure 1.

Complete blood cell count-derived parameters, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), have recently been applied to neurological diseases as sensitive biomarkers for early diagnosis and accurate prognosis. Among diseases in this field, cerebrovascular diseases and primary and secondary brain tumors are the conditions in which these parameters have been studied better, showing good effectiveness as predictive and prognostic biomarkers. However, they have been found useful in multiple sclerosis, Alzheimer’s disease, and bipolar disorders, thus having great potential in other neurological diseases. Future applications may include neurodegenerative and neuropsychiatric diseases in which neuroinflammation has recently emerged as a key pathogenetic mechanism.