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. 2021 Sep 26;7:23337214211046419. doi: 10.1177/23337214211046419

Table 1.

Studies selected for review pertaining to telomere length and its role as an aging biomarker.

Telomere Length
Study Title BA Predictor Used Cohort Name (If Applicable) N Results
Telomere length and all-cause mortality: A meta-analysis Telomere length Multiple cohorts 121,749 One standard deviation reduction of leukocytic telomere length corresponded to 13% increased all-cause mortality risk (95% confidence interval 7–19%) (Wang et al., 2018)
Longitudinal trajectories, correlations, and mortality associations of nine biological ages across 20-year follow-up Telomere length, DNAm age (4 types), physiological age, cognitive function, functional aging index, and frailty index Swedish population-based cohort 636 No evidence that telomere length associated with mortality risk (Li et al., 2020)
Leukocyte telomere length is not associated with mortality in older men Telomere length Prospective population-based MrOS-Sweden study 2744 Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) versus tertile 3 (longest); hazard ratio (HR) = 1.05, 95% confidence interval (CI) 0.85–1.28 and HR = 0.97, 95% CI 0.79–1.19, respectively] (Svensson et al., 2014)