Telomere length and all-cause mortality: A meta-analysis |
Telomere length |
Multiple cohorts |
121,749 |
One standard deviation reduction of leukocytic telomere length corresponded to 13% increased all-cause mortality risk (95% confidence interval 7–19%) (Wang et al., 2018) |
Longitudinal trajectories, correlations, and mortality associations of nine biological ages across 20-year follow-up |
Telomere length, DNAm age (4 types), physiological age, cognitive function, functional aging index, and frailty index |
Swedish population-based cohort |
636 |
No evidence that telomere length associated with mortality risk (Li et al., 2020) |
Leukocyte telomere length is not associated with mortality in older men |
Telomere length |
Prospective population-based MrOS-Sweden study |
2744 |
Using Cox proportional hazards regression, tertile of LTL did not associate with all-cause mortality [tertile 1 (shortest) or 2 (middle) versus tertile 3 (longest); hazard ratio (HR) = 1.05, 95% confidence interval (CI) 0.85–1.28 and HR = 0.97, 95% CI 0.79–1.19, respectively] (Svensson et al., 2014) |