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. 2021 Sep 13;12:733420. doi: 10.3389/fphar.2021.733420

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Copyright © 2021 Guo, Zheng, He, Zhang, Zhang, Wang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of the experimental design and functional assessments of NMD and control rats following SCI. (A) Schematic illustrating the chronological order of experiments for SCI, drug administration, and functional assessments. (B) Significant improvements in Basso, Beattie, and Bresnahan (BBB) scores were observed in NMD-treated rats (n = 11 in each group). Generalized estimating equation, p = 0.008 (week 5), 0.013 (week 6), 0.012 (week 7), 0.016 (week 8), 0.004 (week 9), 0.008 (week 10), 0.006 (week 11), and 0.005 (week 12). *p < 0.05, **p < 0.01. (C) Hind limb grip strength test (n = 11 rats in each group). Two-way repeated-measures ANOVA, p > 0.05, F (1, 20) = 0.284. (D–F) Open-field spontaneous activity test (n = 11 rats in each group). Unpaired t-test, p > 0.05.