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. 2021 Sep 13;12:733420. doi: 10.3389/fphar.2021.733420

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Copyright © 2021 Guo, Zheng, He, Zhang, Zhang, Wang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term administration of NMD reduces the lesion area and promotes sparing of perilesional neurons. (A) Injured spinal cord stained with HE showing the epicenter of the lesion at 12 weeks postinjury. (B) The mean lesion area (%) was quantified by considering the total volume of the spinal cord. NMD-treated rats showed a significantly reduced lesion area relative to controls (n = 11 rats in each group). Unpaired t-test, t (20) = 2.628, p = 0.0161. (C–D) Representative images of horizontal sections of injured spinal cord at 12 weeks post-SCI immunostained with the neuronal marker NeuN. The boxed region in each image is magnified in the corresponding panel c, d to show NeuN + neurons. (E) NMD-treated rats showed significantly higher perilesional neuronal sparing than controls (n = 6 rats in each group). Unpaired t-test, t (10) = 3.021, p = 0.0129.