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. 2021 Sep 13;12:733420. doi: 10.3389/fphar.2021.733420

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Copyright © 2021 Guo, Zheng, He, Zhang, Zhang, Wang, Chen and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term administration of NMD reduces CGRP⁺ fiber sprouting in the lumbar spinal cord. (A–B) Representative images of CGRP immunostaining in the L5 dorsal horn from control or NMD-treated rats. The boxed region in each image is magnified in the corresponding panel a, b showing CGRP⁺ fibers. (C) Long-term treatment with NMD reduces the proportional area of CGRP⁺ axons in lamina I–II and lamina III–V (n = 6 rats in each group). Unpaired t-test, lamina I–II, t (10) = 3.445, p = 0.0063; lamina III–V, t (10) = 3.063, p = 0.012.