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. Author manuscript; available in PMC: 2021 Sep 28.
Published in final edited form as: Biomacromolecules. 2021 Feb 16;22(3):1261–1272. doi: 10.1021/acs.biomac.0c01767

Scheme 1. Split-Complementation Endosomal Escape (SEE) pathways for NG delivering tagged casp-3 (C3-11).

Scheme 1.

Only once nanogels (NG) escape the endosome into the cytosol will C3-11 be released by cytosolic glutathione, leading to reassembly with cytosolically expressed GFP1-10 and GFP fluorescence.