Table1.
Clinical Trials of Wnt Modulators in cancer.
| Mechanism | Agent | Disease | Status | Identifier |
|---|---|---|---|---|
| PORCN inhibitor | WNT974/LGK974 | Squamous Cell Carcinoma, Head And Neck | Withdrawn | NCT02649530 |
| Metastatic Colorectal Cancer | Completed | NCT02278133 | ||
| Pancreatic CancerBRAF Mutant Colorectal CancerMelanomaTriple Negative Breast CancerHead and Neck Squamous Cell CancerCervical Squamous Cell CancerEsophageal Squamous Cell CancerLung Squamous Cell Cancer |
Recruiting | NCT01351103 | ||
| CGX1321 | Solid Tumors GI Cancer |
Recruiting | NCT02675946 | |
| RXC004 | Cancer Solid Tumor |
Not yet recruiting | NCT03447470 | |
| ETC-1922159 | Solid Tumors | Active, not recruiting | NCT02521844 | |
| Wnt-5a protein | Foxy-5 | Colon Cancer | Recruiting | NCT03883802 |
| Metastatic Breast Cancer Colorectal Cancer Prostate Cancer |
Completed | NCT02020291 | ||
| DKK1 antibody | DKN-01 | Hepatocellular Carcinoma | Recruiting | NCT03645980 |
| Endometrial Cancer Uterine Cancer Ovarian Cancer |
Recruiting | NCT03395080 | ||
| Esophageal Neoplasms Adenocarcinoma of the Gastroesophageal Junction Gastroesophageal Cancer Squamous Cell Carcinoma Gastric Adenocarcinoma |
Recruiting | NCT02013154 | ||
| Wnt signaling pathway inhibitor | SM08502 | Solid Tumor | Recruiting | NCT03355066 |
| XNW7201 | Advanced Solid Tumors | Not yet recruiting | NCT03901950 | |
| CBP/beta-catenin Antagonist | PRI-724 | Colorectal Adenocarcinoma Stage IVA Colorectal Cancer Stage IVB Colorectal Cancer |
Withdrawn | NCT02413853 |
| Acute Myeloid Leukemia Chronic Myeloid Leukemia |
Completed | NCT01606579 | ||
| CWP232291 | Acute Myeloid Leukemia Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Myelofibrosis Colon Cancer |
Completed | NCT01398462 | |
| AXIN1 activator | Niclosamide | Colon Cancer | Recruiting | NCT02687009 |
| Wnt signaling modulator | Resveratrol | Colon Cancer Cancer |
Completed | NCT00256334 |