Table 2.
Risk of Adverse Outcomes in Patients With and Without POAF
| Event | Overall | No POAF, n=3846 | POAF, n=778 | Unadjusted Relative Risk | Adjusted Relative Risk | ||
|---|---|---|---|---|---|---|---|
| Incidence* | Incidence* | n (%) | Incidence* | n (%) | HR; 95% CI; P Value | HR; 95% CI; P Value† | |
| Death, myocardial infarction, stroke | 4.44 | 4.01 | 743 (19) | 6.68 | 239 (31) | 1.70; 95% CI, 1.47–1.96; <0.0001 | 1.36; 95% CI, 1.16–1.59; 0.0001 |
| Death | 2.90 | 2.59 | 480 (12.5) | 4.52 | 162 (20.8) | 1.73; 95% CI, 1.45–2.07; <0.0001 | 1.33; 95% CI, 1.10–1.61; 0.003 |
| Cardiovascular | 2.03 | 1.86 | 344 (8.9) | 2.90 | 104 (13.4) | 1.55; 95% CI, 1.24–1.93; <0.0001 | 1.19; 95% CI, 0.94–1.50; 0.14 |
| Noncardiovascular | 0.88 | 0.73 | 136 (3.5) | 1.62 | 58 (7.5) | 2.21; 95% CI, 1.62–3.00; <0.0001 | 1.68; 95% CI, 1.21–2.33; 0.002 |
| Myocardial infarction | 1.61 | 1.42 | 263 (6.8) | 2.60 | 93 (12) | 1.81; 95% CI, 1.42–2.29; <0.0001 | 1.58; 95% CI, 1.23–2.02; 0.0004 |
| Stroke | 0.50 | 0.45 | 84 (2.2) | 0.75 | 27 (3.5) | 1.63; 95% CI, 1.06–2.52; 0.027 | 1.27; 95% CI, 0.81–2.00; 0.30 |
AF indicates atrial fibrillation; HR, hazard ratio; and POAF, perioperative atrial fibrillation.
*
Incidence per 100 person‐years of follow‐up.
†
All models are adjusted for age, sex, smoking, history of hypertension, history of diabetes mellitus, history of heart failure, history of myocardial infarction, history of peripheral artery disease, history of stroke, urgent surgery, and randomized treatment assignment. Because of missing covariate data, the multivariable models included 4545 patients (98.3%).