Table 4.
Proteins Being Associated With Incident Ischemic Stroke in a Meta‐Analysis of ULSAM and PIVUS
| Protein | Age Adjusted | Adjustment for Traditional Risk Factors | ||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI Lower | 95% CI Higher | P Value | HR | 95% CI Lower | 95% CI Higher | P Value | |
| NTproBNP | 1.69 | 1.41 | 2.01 | 6.25e‐09 | 1.70 | 1.41 | 2.06 | 2.61e‐08* |
| GDF‐15 | 1.41 | 1.21 | 1.65 | 0.000011 | 1.35 | 1.13 | 1.61 | 0.00068* |
| Osteoprotegerin | 1.42 | 1.21 | 1.67 | 0.000017 | 1.36 | 1.15 | 1.61 | 0.00025* |
| TRAIL‐R2 | 1.30 | 1.15 | 1.48 | 0.000031 | 1.27 | 1.11 | 1.46 | 0.00062* |
| CSF‐1 | 1.38 | 1.18 | 1.63 | 0.000073 | 1.34 | 1.12 | 1.60 | 0.0010* |
| Adrenomedullin | 1.43 | 1.19 | 1.71 | 0.00010 | 1.41 | 1.17 | 1.71 | 0.00032* |
| Follistatin | 1.32 | 1.14 | 1.54 | 0.00023 | 1.28 | 1.10 | 1.50 | 0.0010* |
| TIM‐1 | 1.29 | 1.11 | 1.50 | 0.00055 | 1.21 | 1.03 | 1.42 | 0.018* |
Hazard ratios (HRs) are given for a 1‐SD increase in the proteins. Only proteins with age‐ or sex‐adjusted P value <0.000625 and a multi‐adjusted P value <0.05 are shown. CSF‐1 indicates macrophage colony‐stimulating factor 1; GDF‐15, growth/differentiation factor 15; NTproBNP, N‐terminal pro‐B‐type natriuretic peptide; PIVUS, the Prospective Investigation of Uppsala Seniors Study; TIM‐1, T‐cell immunoglobulin and mucin domain 1; TRAIL‐R2, TNF‐related apoptosis‐inducing ligand receptor 2; and ULSAM, Uppsala Longitudinal Study of Adult Men.
*
P<0.05 also after adjustment for estimated glomerular filtration rate.