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. 2021 May 29;10(12):e019091. doi: 10.1161/JAHA.120.019091

Figure 2. PLGA microparticles are within a size range for inhalation and release verteporfin and CB‐839 in a sustained manner.

Figure 2

(A) Scanning electron microscope images of CB‐839 alone encapsulated, verteporfin alone encapsulated, and CB‐839 with verteporfin encapsulated microparticles displayed smooth surface morphology. (B) Size distribution of the microparticles obtained from dynamic light scattering experiments demonstrated that the average microparticle size for all the microparticles was approximately 1 μm. (C) Release kinetics of CB‐839 from PLGA microparticles encapsulating CB‐839‐verteporfin or encapsulating CB‐839 only. (D) Release kinetics of verteporfin from PLGA microparticles encapsulating CB‐839‐verteporfin or encapsulating verteporfin only. Error bars represent SD. PLGA indicates poly(lactic‐co‐glycolic) acid.