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. 2021 May 29;10(12):e019091. doi: 10.1161/JAHA.120.019091

Figure 5. Delivery of verteporfin and CB‐839 simultaneously in vivo improves hemodynamic manifestations of PH in monocrotaline‐exposed rats.

Figure 5

(A) Poly(lactic‐co‐glycolic) acid MP delivering verteporfin and CB‐839 and poly(lactic‐co‐glycolic) acid MP delivering verteporfin alone significantly decreased the Fulton index (RV/LV+S mass) compared with blank MP. (B) PLGA MP delivering verteporfin and CB‐839 significantly decreased RVSP compared with the control of blank MP, and this RVSP was not significantly different than the untreated rats (n=3–6; error bars represent mean±SEM. By 1‐way ANOVA and post hoc Bonferroni testing, significantly different values are represented by *<0.05, *<0.01, ***<0.001, and ****<0.00001. LV+S indicates left ventricle+septum; MP, microparticles; RV, right ventricle; and RVSP, right ventricular systolic pressure.