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. 2021 May 29;10(12):e019521. doi: 10.1161/JAHA.120.019521

Figure 4. The effects of IL‐1β neutralizing antibody on myocardial inflammation and infarct size.

Figure 4

*P<0.05, unpaired t tests. A, IR‐injured hearts harvested from CypD‐KO mice were subjected to flow cytometric analysis. The number of monocytes were normalized by IS. The data are mean±SD (n=5 per group). *P<0.05, unpaired t tests. B, The therapeutic effects of IL‐1β neutralizing antibody on the infarct size in WT, CypD‐KO or CCR2‐KO mice subjected to 60 minutes of myocardial ischemia followed by 24 hours of reperfusion. The horizontal lines represent mean±SD (n=4–8 per group). CCR2‐KO indicates C‐C chemokine receptor 2‐knockout mice; Ctrl, control; CypD‐KO, cyclophilin D‐knockout mice; IgG, immunoglobulin G; IL‐1β, interleukin‐1β; IR, ischemia‐reperfusion; IS, infarct size; and WT indicates wild‐type mice.