Table 1.
Baseline Characteristics of Study Participants, Stratified by Pooled Cohort Equation‐Based Risk Categories
| Low/Borderline Risk, PCE<7.5%, n=13 899 | Intermediate Risk, PCE 7.5% to <20%, n=6625 | High Risk, PCE≥20%, n=2418 | |
|---|---|---|---|
| No. by cohort | |||
| Age, y, mean (SD) | 54.9 (7.3) | 63.3 (8.2) | 68.3 (8.6) |
| Women, % | 64.9 | 42.8 | 37.4 |
| Race | |||
| White, % | 64.2 | 72.2 | 80.6 |
| Black, % | 22.8 | 22.7 | 18.2 |
| Other, % | 13.0 | 5.1 | 1.1 |
| Total cholesterol, mg/dL, mean (SD) | 203 (37.5) | 214 (41.9) | 218 (45.3) |
| HDL‐C, mg/dL, mean (SD) | 55.4 (16.9) | 48.3 (14.3) | 46.9 (13.4) |
| LDL‐C, mg/dl, mean (SD) | 125 (34.9) | 139 (39.1) | 141 (41.4) |
| Untreated SBP, mm Hg, mean (SD) | 115 (15) | 129 (18) | 145(22) |
| Treated SBP, mm Hg, mean (SD) | 123 (16) | 134 (18) | 149 (21) |
| Blood pressure medications, % | 18 | 39.4 | 57.6 |
| Current smoker, % | 14.6 | 28.7 | 30.5 |
| Diabetes mellitus, % | 3.1 | 14.1 | 46.1 |
| Statin use, % | 5.4 | 4.0 | 1.2 |
| Triglyceride ≥175 mg/dL, % | 13.4 | 24.6 | 32.7 |
| LDL‐C ≥160 mg/dL, % | 15.8 | 27.5 | 29.3 |
| Non–HDL‐C ≥190 mg/dL, % | 13.7 | 26.7 | 29.4 |
| Metabolic syndrome, % | 17.8 | 38.2 | 55.2 |
| CKD, % | 3.5 | 14.2 | 29.1 |
| ABI ≤0.9, % | 2.5 | 5.4 | 12.4 |
| hs‐CRP ≥2 mg/dL, % | 46.0 | 53.7 | 62.1 |
| Lp(a) ≥50 mg/dL, % | 22.0 | 35.5 | 38.5 |
| apoB ≥130 mg/dL, % | 8.9 | 20.2 | 25.1 |
| Family history of premature CVD, % | 13.7 | 15.3 | 14.0 |
| CAC >0 Agatston unit, % | 37.7 | 65.8 | 78.6 |
ABI indicates ankle‐brachial index; apoB, apolipoprotein B; CAC, coronary artery calcium; CKD, chronic kidney disease; CVD, cardiovascular disease; HDL‐C, high‐density lipoprotein cholesterol; hs‐CRP, high‐sensitivity C‐reactive protein; LDL‐C, low‐density lipoprotein cholesterol; Lp(a), lipoprotein (a); PCE, pooled cohort equation; and SBP, systolic blood pressure.
P<0.001 for all comparison (except Lp(a), P=0.07; and family history of premature CVD, P=0.02). P value was based on χ2 test for categorical variables and ANOVA or Kruskal‐Wallis test (as appropriate) for continuous variables.