Table 3.
Risk Reclassification of MESA Participants by Aggregate Risk Enhancer Score ≥3
| PCE Alone | PCE With Aggregate Risk Enhancer ≥3 | Risk Reclassification | ||||
|---|---|---|---|---|---|---|
| <7.5% | 7.5% to <20% | ≥20% | Row Total | Higher, No. (%) | Lower, No. (%) | |
| Events, n=305 | ||||||
| <7.5% | 154 | 11 | 165 | 11 (6.7) | NA | |
| 7.5%–20% | 3 | 113 | 5 | 121 | 5 (4.1) | 3 (2.5) |
| ≥20% | 2 | 17 | 19 | NA | 2 (10.5) | |
| Total | 157 | 126 | 22 | 305 | 16 (5.2) | 5 (1.6) |
| Nonevent, n=6105 | ||||||
| <7.5% | 5,034 | 54 | 5,088 | 54 (1.1) | NA | |
| 7.5%–20% | 83 | 826 | 14 | 923 | 14 (1.5) | 83 (9.0) |
| ≥20% | 13 | 81 | 94 | NA | 13 (13.8) | |
| Total | 5117 | 893 | 95 | 6,105 | 68 (1.1) | 96 (1.6) |
| Net reclassification improvement | ||||||
| Overall, P=0.007 | 4.1% | … | ||||
| Intermediate group, 7.5%–<20% | 9.1% | … | ||||
MESA indicates Multi‐Ethnic Study of Atherosclerosis; NA, not applicable; and PCE, pooled cohort equation.