Table 4.
Risk Reclassification of MESA Participants by CAC Score
| PCE Alone | PCE With CAC>0 | Risk Reclassification | ||||
|---|---|---|---|---|---|---|
| <7.5% | 7.5% to <20% | ≥20% | Row Total | Higher, No (%) | Lower, No (%) | |
| Events, n=305 | ||||||
| <7.5% | 131 | 34 | 165 | 34 (20.6) | NA | |
| 7.5% to <20% | 16 | 95 | 10 | 121 | 10 (8.3) | 16 (13.2) |
| ≥20% | 2 | 17 | 19 | NA | 2 (10.5) | |
| Total | 147 | 131 | 27 | 305 | 44 (14.4) | 18 (5.9) |
| Nonevent, n=6105 | ||||||
| <7.5% | 4821 | 267 | 5088 | 267 (5.2) | NA | |
| 7.5% to <20% | 192 | 710 | 21 | 923 | 21 (2.3) | 192 (20.8) |
| ≥20% | 21 | 73 | 94 | NA | 21 (22.3) | |
| Total | 5013 | 998 | 94 | 6,105 | 288 (4.7) | 213 (3.5) |
| Net reclassification improvement | ||||||
| Overall, P=0.005 | 7.3% | … | ||||
| Intermediate group (7.5% to <20%) | 13.6% | … | ||||
CAC indicates coronary artery calcium; MESA, Multi‐Ethnic Study of Atherosclerosis; NA, not applicable; and PCE, pooled cohort equation.