FIGURE 4.

Proof of concept study—Circulating α‐ and γ‐tocopherol concentrations in eNAD/EDM and control horses: Both serum α‐TOH (A) and γ‐TOH (B) levels increased significantly during supplementation (P < .0001), with no effect of disease (P = .46). A significant increase was observed in CSF α‐TOH (C; P = .02), but not γ‐TOH (D) concentrations between time points but not disease conditions. Post hoc analysis showed that CSF α‐TOH tended to increase in the 28‐day control horses only (P = .08). Supplementation began at 0 days. The 0.25, 0.5, and 1‐day increments represent time points within the first 24 hours (ie, 6, 12, and 24 hours)