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. 2021 Jul 31;35(5):2473–2485. doi: 10.1111/jvim.16233

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© 2021 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Validation study—Metabolic ratios change with supplementation and α‐metabolic ratio differs between eNAD/EDM, CVCM, and control horses: A, Alpha‐metabolic ratios changed significantly with time (P < .0001) and disease status (P = .03), with no interaction of disease status and time (P = .12). Post hoc testing revealed significant differences between eNAD/EDM and CVCM at 18 and 24 hours postsupplementation (P = .03 and P = .02, respectively). B, Gamma metabolic ratios did not differ significantly with time (P < .23) or disease status (P = .46). Data analyzed via ANOVA after log transformation with post hoc contrasts between group means. ****P < .0001