Fig. 4.

Spatial model results for the lethal exposure scenario. A. Spatial distribution of epithelial cells (top), local immune cells (middle) and extracellular virus (bottom) in a simulation replica at 0, 1, 2, 4, 5 and 10 days. Cell types shown as in Fig. 3. The color bar shows contour levels of the extracellular virus distribution. B. Results from 50 simulation replicas of the spatial model (colored lines) compared to ODE model results (black line) for uninfected cells (left), extracellular virus (center), and CD8⁺ T cells (right).