Table 1. Baseline characteristics of the subjects.
| Variable | Treatment assigned | Respiratory support at randomization | ||
|---|---|---|---|---|
| Placebo n = 108(%) | Hydroxychloroquine n = 106(%) | No mechanical ventilation n = 52(%)* | Mechanical ventilation n = 162(%) | |
| Age (years) | 49(12) | 50(11) | 47(13) | 50(12) |
| Men | 74(68) | 87(82) | 36(69) | 125(77) |
| Mean days from symptom onset | 7.5(3) | 7.4 (3) | 7.5(2.8) | 7.4 (3.1) |
| Mean days from hospital admission to randomization | 2.5(1.5) | 2.6(1.8) | 2.2(1.5) | 2.6(1.7) |
| <10 days of symptoms (%) | 80(49.7) | 81(50.3) | 37(23) | 124(77) |
| Use of supplementary oxygen, including high flow oxygen (%) | 27(25) | 25(24) | -- | -- |
| Mechanical ventilation (%) | 81(75) | 81(76) | None | All |
| Hemodyalisis | 8 (7.4) | 6 (5.7) | 0/52 | 14/162 (8.6) |
| Use of vasopressors | 39/105 (37) | 41/106 (39) | 0/51 | 80/160 (50) |
| No coexisting condition | 39(36) | 34(32) | 28(54) | 45(28) |
| Diabetes | 14(13) | 20(19) | 6(12) | 28(17) |
| Obesity | 51(47) | 50(47) | 20(38) | 81(50) |
| High blood pressure | 19(18) | 17(16) | 10(21) | 26(16) |
| Current smoking | 9(8) | 14(13) | 6(12) | 17(10) |
| Pack-years of cumulative smoking | 3(2) | 3(4) | 3(3) | 3(3) |
| HIV or immunosuppressed | 0 | 1 | 0 | 1 |
| Liver disease | 0 | 0 | 0 | 0 |
| Kidney disease | 0 | 0 | 0 | 0 |
| Score in the risk for QTc prolongation | 3(2) | 3(2) | 3(2) | 3(2) |
| QTc at baseline (ms) | 407(47) | 413(26) | 403(45) | 411(38) |
Continuous variables are expressed in mean and standard deviation; categorical variables are expressed in percentage. P was obtained by the Student´s t–test for continuous variables and by the chi2 for categorical variables. HCQ = hydroxychloroquine.
*Include patients with oxygen therapy and high flow nasal prongs.
No participant received non-invasive ventilation or ECMO.