In this retrospective cohort study of 14,343 patients, seven out of 32 previously published prognostic scores were able to fairly predict 30-day in-hospital mortality using routinely collected clinical and biological data (area under the ROC curve > 0.75). The 4C Mortality Score and the ABCS stand out because they performed as well in our cohort and their initial validation cohort, during the first and subsequent epidemic waves, in younger and older patients, and showed satisfactory calibration. Their ability to guide clinical management decisions and appropriate resource allocation should now be evaluated in future studies.