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. 2021 Sep 28;16:399. doi: 10.1186/s13023-021-02021-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Recruitment details of the HAEKA study as per 07.10.2020. a Number of participants enrolled per study site. b A boxplot displaying the age distribution of the participants. c Gender distribution of the participants. d Visit status of all participants in the HAEKA study. The number of completed Visits 1–7 is shown. e Prophylactic treatment of HAEKA participants: it is shown how many participants take each respective medication (one subject received both Lanadelumab and Berinert®). f An overview showing how often the different samples a–f of each attack have been collected. g Acute treatment of HAE attacks: it is shown how many percent of the participants take a respective medication to treat an attack. h Overview on the amount of documented attacks per participant. i Exemplary CentoCard® showing the quality of participant’s self-sampled blood spots