Kaplan-Meier analysis of PFS for patients with U/M GIST treated with avapritinib or regorafenib in (A) the ITT population, (B) patients who received the study drug as third line treatment, (C) patients who received study drug as fourth line treatment, (D) patients with PDGFRA D842V–mutant GIST, and (E) patients in the ITT population who did not have PDGFRA D842V–mutant GIST. GIST, GI stromal tumor; HR, hazard ratio; ITT, intention-to-treat; NR, not reached; PDGFRA, platelet-derived growth factor receptor alpha; PFS, progression-free survival; U/M, unresectable or metastatic.