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. 2021 Sep 24;14:4901–4914. doi: 10.2147/OTT.S286326

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© 2021 Zhang et al.

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BM-MSCs-derived exosomal miR-425-5p inhibits viability and induces apoptosis of AML cells. (A–C) The exosomes were extracted from the BM-MSCs cells treated with control mimic or miR-425-5p mimic, and the KG-1A and THP-1 cells were further treated with the exosomes. (A) The cell proliferation was measured by colony formation assay in the cells. (B) The cell apoptosis was measure by flow cytometry analysis in the cells. (C) The expression of PARP, cleaved PARP (c-PARP), caspase3, cleaved caspase3 (c-caspase3), and β-actin was assessed by Western blot analysis in the cells. The results of Western blot analysis were quantified by ImageJ software. Data are presented as mean ± SD. Statistic significant differences were indicated: ***P < 0.001.