Figure 2.

Animal groups versus enzymes box showing the relevant similarities found between the human orthologous sequence baits for the thirteen enzymes (see table 2 for details) and the different animal lineages. The score reported (see electronic supplementary material for the exact values) is the ‘Max score’, i.e. the highest alignment score (bit-score) between the query sequence and the sequence segment found within the database. Score code: greater than 500, navy blue; 100–500, blue; less than 100, pale blue; and no significant match, white. For the matching details (including sequences codes and scores) between the human orthologues and the various groups, see electronic supplementary material. The asterisks mark the four enzymes that are more conserved (POMT1, POMT2, POMGnT1 and LARGE1) while the red triangles highlight B3GALNT2, POMGnT1 and B4GAT1, for which orthologues are present in all the lineages analysed.