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. 2021 Sep 29;11(9):210104. doi: 10.1098/rsob.210104

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — A multiple alignment of human LARGE1 and LARGE2 sequences with those from elephant shark (Chondrichthyes) and sea lamprey (Cyclostomata), showing the organization and conservation of the two subsequent catalytic domains oriented towards the Golgi lumen [70]. The two human LARGE1 catalytic domains are highlighted in red (xylosyltransferase domain) and green (glucuronyltransferase domain), respectively. Codes: Hs, Homo sapiens; Cm, Callorhinchus milii (elephant shark); Pm, Petromyzon marinus (lamprey). Asterisk: identical residues; colon: conserved substitutions; dot: semi-conserved substitutions.