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. 2021 Sep 29;11(9):210106. doi: 10.1098/rsob.210106

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 1. — Regulation of ANGPTL8 expression during fasting/fed. Under feeding conditions, the increase of insulin, glucose and FA can increase the expression of ANGPTL8 through a variety of pathways. PI3K/Akt, LXRα, ChREBP, SREBP-1c, C/REBPβ, HNF-1α and VDR may participate in this process. Under fasting condition, GR signal inhibited the transcription of ANGPTL8. At the same time, PPARα competes with LXR to bind to RXR, which inhibits the induction of ANGPTL8 expression by LXR.