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. 2021 Sep 29;11(9):210106. doi: 10.1098/rsob.210106

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© 2021 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Compensatory increase of ANGPTL8 in pathological state improves metabolism. Insulin resistance occurs in the pathological state of diabetes and obesity, which leads to a variety of metabolic disorders in liver, fat and muscle. Hyperinsulinaemia, glucose, FA and stress induced compensatory increase of ANGPTL8. ANGPTL8 not only improves insulin sensitivity by enhancing Akt phosphorylation, but also enhances the storage and buffering capacity of WAT, reducing the damage of ectopic lipid pile and lipid toxicity in other tissues.